Publisher’s Note: This is a work of fiction. Without limiting the rights under copyright reserved above, no part of this publication may be reproduced, stored or introduced into a retrieval system, or transmitted, in any form or by any means (electronic, mechanical, photocopying, recording or otherwise), without prior written permission of both the copyright owner and the above publisher of this book. doi: 10.1016/j.ijrobp.20.No part of this eBook may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the author. SBRT-Partial Tumor Irradiation for The Treatment of Unresectable Bulky NSCLC. Tubin S., Grusch M., Popper H.H., Brcic L., Jeremic B.

Novel stereotactic body radiation therapy (SBRT)-based partial tumor irradiation targeting hypoxic segment of bulky tumors (SBRT-PATHY): Improvement of the radiotherapy outcome by exploiting the bystander and abscopal effects. Combined High-Dose LATTICE Radiation Therapy and Immune Checkpoint Blockade for Advanced Bulky Tumors: The Concept and a Case Report. Jiang L., Li X., Zhang J., Li W., Dong F., Chen C., Lin Q., Zhang C., Zheng F., Yan W., et al.

A current review of spatial fractionation: Back to the future? Int. The optimal utilization proportion of external beam radiotherapy in European countries: An ESTRO-HERO analysis. GRID radiotherapy non-conventional radiotherapy organ sparing protons therapeutic index.īorras J.M., Lievens Y., Dunscombe P., Coffey M., Malicki J., Corral J., Gasparotto C., Defourny N., Barton M., Verhoeven R., et al. The goal of this article was to highlight the current knowledge on the molecular and radiobiological mechanisms behind spatially fractionated radiotherapy and to present the up-to-date preclinical and clinical evidence towards the therapeutic potential of this technique involving both photon and proton beams.

Non-conventional irradiation techniques, such as spatially fractionated radiotherapy, have been developed to tackle some of these challenges and to offer a high therapeutic index when treating radioresistant tumours. Hypoxic subvolumes, a subpopulation of cancer stem cells, as well as the inherent or acquired radioresistance define tumour aggressiveness and metastatic potential, which remain a therapeutic challenge. Investigations into the complexity of tumour radiobiology confirmed the high heterogeneity of tumours as being responsible for the often poor treatment outcome.

The continuously evolving field of radiotherapy aims to devise and implement techniques that allow for greater tumour control and better sparing of critical organs.

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